Abstract
Anemia is commonly seen in preterm infants. It may reduce the capacity of hemoglobin to transport oxygen throughout the body and may result in tissue and organ dysfunction. This study aimed to investigate the effect of anemia on the development of bronchopulmonary dysplasia (BPD) in preterm infants. 243 infants who were admitted to BaYi Children’s Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital with gestational age (GA) less than 32 weeks from February, 2014 to February, 2015 were included in the study. Maternal and infant data were recorded. Multivarariate logistic regression analysis was performed to determine the association between anemia and BPD. Of 243 preterm infants, the incidence of anemia was higher in BPD patients than non-BPD patients (p < 0.001). Mean Hct in BPD patients was lower than non-BPD patients at different time points in 1d, 7d, 14d, and 21d. Controlling for other confounding factors, early anemia was associated with an increased risk of BPD. Number of transfusions is also a significant risk factor for BPD (p = 0.001). Therefore, prevention and treatment of early anemia is necessary and reducing number of transfusions may reduce the incidence of BPD in preterm infants.
Highlights
Anemia is commonly seen in preterm infants
The incidence of patent ductus arteriosus (PDA) and retinopathy of prematurity (ROP) was significantly higher in Bronchopulmonary dysplasia (BPD) patients than non-BPD patients (83.1% vs. 66.9%, p = 0.011; 49.3% vs. 8.7%, p < 0.001; respectively)
A prospective study conducted by Ramakishnan K. and his colleagues showed that anemia was a risk factor for childhood asthma[23]
Summary
Anemia is commonly seen in preterm infants. It may reduce the capacity of hemoglobin to transport oxygen throughout the body and may result in tissue and organ dysfunction. This study aimed to investigate the effect of anemia on the development of bronchopulmonary dysplasia (BPD) in preterm infants. Prevention and treatment of early anemia is necessary and reducing number of transfusions may reduce the incidence of BPD in preterm infants. A number of potential risk factors have been reported to be associated with the development of BPD, including premature birth, low birth weight (BW), genetic predisposition, prolonged mechanical ventilation , hyperoxia, infections, and patent ductus arteriosus (PDA)[5,6,7,8,9,10,11,12,13]. We performed a prospective study to investigate the association of anemia with the development of BPD in preterm infants. We investigated whether early anemia affected the development of BPD
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