Abstract
BackgroundA genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited.MethodsWe conducted a case-control study in 481 patients with colorectal cancer (CRC) and 962 sex-age matched non-cancer controls. Data on lifestyle factors, including diet, were obtained by self-administered questionnaire. Two 8q24 loci, rs6983267 and rs10090154, were assessed by the TaqMan method. Associations were then assessed by multivariate logistic regression models that considered potential confounders.ResultsWe found an increased risk of CRC with rs6983267 but not with rs10090154. An allelic OR was 1.22 (1.04-1.44, p for trend = 0.014), which remained significant after adjustment for confounders (OR = 1.25). No statistically significant interaction with potential confounding factors was observed.ConclusionThe polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted.
Highlights
A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk
Subjects Cases were 481 patients who were histologically diagnosed with Colorectal cancer (CRC) (245 with colon cancer, 231 with rectum cancer) between January 2001 and November 2005 at Aichi Cancer Center Hospital (ACCH) and who had no prior history of cancer
(page number not for citation purposes) http://www.biomedcentral.com/1471-2407/9/379 controls matched for sex and age
Summary
A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Several a number of genome-wide association studies (GWAS) have revealed an association between variants on chromosome 8q24 and several sites of cancer, including CRC [2,3,4,5,6,7,8,9,10,11]. Each study showed that rs6983267 resides in 128.47-128.54 MB on Chromosome 8, denoted as ‘region 3,’ [7] and consistently associated with CRC [6,9,12] This association was confirmed in a subsequent large-scale replication study in Caucasians [13,14,15,16,17,18]. We explored the gene-environmental interaction between potential confounders and rs6983267
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