Association between allopurinol use and Parkinson's disease in older adults.

Abstract

Little evidence is available about the association between allopurinol use and Parkinson's disease. The present study aimed to explore the association between allopurinol use and Parkinson's disease in older adults in Taiwan. We conducted a population-based case-control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65years with newly diagnosed Parkinson's disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65years without Parkinson's disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as subjects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson's disease. The OR of Parkinson's disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use. No association can be detected between allopurinol use and Parkinson's disease in older adults in Taiwan.