Abstract
To date, the relationship between the aldehyde dehydrogenases-2 (ALDH2) rs671 G>A (Glu504Lys) polymorphism and gastric cancer (GC) risk has not been thoroughly elucidated. To derive a more precise estimation of the effect of the ALDH2 rs671 G>A polymorphism on GC, we conducted this meta-analysis. We searched for qualified studies in the Embase, PubMed, Wang Fan and China National Knowledge Infrastructure databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association. A total of 6,421 GC patients and 8,832 control subjects were included in the present study. The pooled results indicated no significant relationship between the ALDH2 rs671 G>A polymorphism and GC susceptibility in all genetic models. A stratified analysis by country showed that the ALDH2 rs671 G>A polymorphism might be a risk factor for GC in Japan (Allele model: P unadjusted = 0.034; Dominant model: P unadjusted = 0.040); however, the result was nonsignificant when the Bonferroni correction and false discovery rate (FDR) were applied. In subgroup analyses by drinking status in the dominant model, our study revealed that the ALDH2 rs671 G>A polymorphism significantly increased the risk of GC for drinkers (dominant model: P < 0.001). No relationship between the ALDH2 rs671 G>A polymorphism and GC risk was observed in any other subgroup. Our present study indicated no association between the ALDH2 rs671 G>A polymorphism and GC risk in Eastern Asian populations. However, the ALDH2 rs671 G>A polymorphism can significantly increase GC risk for drinkers.
Highlights
Gastric cancer (GC) is a frequent malignant tumour and is one of the primary causes of tumour-associated deaths in the world
The full text of the rest of the studies was reviewed, and 9 of these full-text studies were removed for the following reasons: 4 studies did not have sufficient data, 1 had data covered by another study, 1 had data that overlapped with another, and 3 were not relevant to the aldehyde dehydrogenases-2 (ALDH2) rs671 G>A polymorphism
The author provided only the GG and GA + AA genotype counts of cases and controls without specific information on either the AA or GA genotype; the dominant model was employed to assess the association between the ALDH2 rs671 G>A polymorphism and gastric cancer (GC) risk in the stratified analysis according to drinking status, sex and smoking status
Summary
Gastric cancer (GC) is a frequent malignant tumour and is one of the primary causes of tumour-associated deaths in the world. In 2012, 951,600 patients were diagnosed with GC, accounting for 8% of cancer cases, and 723,100 patients died of GC, accounting for 10% of cancer deaths [1]. In many Western countries, the incidence of stomach cancer has gradually decreased. It has been generally accepted that occurrence of stomach cancer is a multistep, complex and multifactorial process that involves diverse risk factors. People are exposed to the above factors, not all of them will develop GC, indicating that genetic factors are involved in the development of GC [5]. Single nucleotide polymorphisms (SNPs), the most frequent type of genetic mutations, may contribute to an individual’s susceptibility to GC
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