Abstract

We investigated single-nucleotide polymorphisms (SNPs) in the aldehyde dehydrogenase family1 L1 gene (ALDH1L1) and their association with neural tube defects (NTDs) in the Chinese population. A total of 271 NTDs cases and 192 healthy controls were used in this study. A total of 112 selected SNPs in the ALDH1L1 gene were analyzed using the next-generation sequencing method. Statistical analysis was carried out to investigate the correlation between SNPs and patient susceptibility to NTDs. Statistical analysis revealed a significant correlation between the SNP sites rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene and NTDs. The TT genotype and Tallele of rs4646733 in ALDH1L1 were associated with a significantly increased incidence of NTDs [odds ratio (OR)=2.16, 95% confidence interval (CI) 1.199-3.896for genotype; and OR=1.46, 95% CI 1.092-1.971for allele]. The AA genotype and Aallele of rs2305225 in ALDH1L1 were associated with a significantly increased incidence of NTDs (OR=2.03, 95% CI 1.202-3.646for genotype, and OR=1.44, 95% CI 1.096-1.905for allele). The CT genotype and Callele of rs2276731 in ALDH1L1 significantly were associated with an increased incidence of NTDs (OR=1.67, 95% CI 1.129-2.491with genotype, and OR=1.32, 95% CI 0.956-1.816with allele).The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for NTDs in the Chinese population.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call