Association between Age-related Cataract and Mortality in Sweden: A Long-term Population-based Follow-up Study

Abstract

ABSTRACT Purpose To assess the relationship of age-related cataract with all-cause mortality in a Swedish population. Methods Cox regression analyses were performed in a cohort of 746 residents 65–74 years of age, examined in a population survey in the rural district of Tierp, Sweden, 1984–86. To expand the sample size, 1,071 people were recruited by means of glaucoma case records established at the Eye Department in Tierp from 1978 to 2007. In this way, the cohort comprised 1,817 subjects, representing nearly 27,000 person-years at risk. The presence of cataract was determined based on retroillumination with lens opacities evident on slit-lamp examination. Information on deaths was obtained from the local population register. Results By the conclusion of the study in April 2020, 1,633 deaths had been reported. Of these cases, 694 were affected by lens opacities or had history of cataract surgery at baseline. In multivariate analysis, including cataract, age, sex, smoking habits, cancer, diabetes, hypertension and ischemic heart disease, no association was found between cataract and mortality (hazard ratio 0.99; 95% confidence interval 0.90–1.10). Adjustment for participation in the population survey had no effect on the estimate. Conclusion In this long-term follow-up study of subjects 65–74-years-old in Sweden, cataract was not associated with all-cause mortality.