Association between adipokines, inflammatory markers and systemic manifestations in chronic obstructive pulmonary disease (COPD) patients

Abstract

Introduction: Recent studies have shown that adipose tissue can contributes to increase systemic inflammation and can be associated to systemic manifestations in COPD. Objectives: The aim of this study was to evaluate adipokines and systemic inflammation COPD patients. Methods: We evaluated 59 mild to very severe COPD patients according to GOLD. Clinical and laboratory evaluation, pre-and post-bronchodilator spirometry, pulse oximetry, body mass index - BMI, fat-free mass - FFM and FFF index, six minute walk distance (6MWD), health status (St. George Respiratory Disease Questionnaire SGRQ and Hospital Anxiety and Depression Scale HAD) were evaluated. Concentrations of interleukin 6 (IL-6), C-reactive protein (CRP), adiponectin and leptin were measured in serum. Results: 13.6% of patients were mild COPD, 45.7% moderate, 25.4% severe and 15.3% very severe. When patients were categorized according to BODE index, adipokines and others systemic inflammation did not differ between groups. However, when categorized according to GOLD, patients with moderate [0.27 (0.20-0.29) vs 0.53 (0.43-0.61) p=0,002] and severe [0.27 (0.20-0.29) vs 0.47 (0.38-0.61) p=0,018] COPD showed higher leptin concentrations than mild COPD. We identified negative correlation of leptin with age (R= -0.41, p=0.001), and positive association of leptin with BMI (R= 0.600, p= Conclusion: Increased adipokines and inflammatory markers were correlated with body composition and exercise capacity in COPD patients.