Abstract
Background: The ADD1 Gly460Trp polymorphism has been linked to essential hypertension (EH) in multiple populations, but the results were inconsistent. The goal of our study is to investigate the contribution of ADD1 Gly460Trp polymorphism and environmental factors to the risk of EH. Methods: We conducted a case-control study including 1020 hypertensive cases and 1020 controls, and the gender and age were well matched between hypertensive and control groups. Blood samples and participants information were also collected. Using the melting temperature shift technology, the ADD1 Gly460Trp polymorphism was genotyped among all subjects. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the ADD1 Gly460Trp polymorphism and the nongenetic factors. Results: Our results showed that body mass index (BMI), total cholesterol, triglycerides, and drinking were significantly associated with EH (P<0.05). In addition, the Gly460Trp polymorphism was found significantly associated with hypertension at allelic level (P<0.01; OR=0.85; 95%CI=0.75-0.96). A breakdown association analysis by gender showed the Gly460Trp polymorphism was associated with EH only in female (P<0.01; OR=0.79; 95%CI=0.68- 0.92). MDR analysis indicated that there was an interaction among BMI, high density lipoprotein, drinking, and rs4961 involved in the risk of EH. Conclusion: The present study indicated the Gly460Trp polymorphism was associated with EH in female Han Chinese, which might contribute to EH via interactions with non-genetic factors.
Highlights
Essential hypertension (EH) is an important worldwide public health issue which contributes to the burden of heart disease, stroke and kidney failure and premature mortality and disability
A breakdown association analysis by gender was performed to explore the association between Gly460Trp polymorphism and essential hypertension (EH) (Table 2)
We found that body mass index (BMI), total cholesterol (TC), TG, and drinking were significantly associated with EH, and they might be the risk factor for EH
Summary
Essential hypertension (EH) is an important worldwide public health issue which contributes to the burden of heart disease, stroke and kidney failure and premature mortality and disability. It disproportionately affects populations in low- and middle-income countries where health systems are weak. The ADD1 Gly460Trp polymorphism has been linked to essential hypertension (EH) in multiple populations, but the results were inconsistent. The goal of our study is to investigate the contribution of ADD1 Gly460Trp polymorphism and environmental factors to the risk of EH
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