Abstract
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557 and childhood asthma in some genetic models. This meta-analysis suggested that ADAM33 polymorphisms rs2280091, rs2280090, rs2787094, rs44707 and rs528557 were significantly associated with a high risk of childhood asthma.
Highlights
Asthma is a common respiratory disorder in both adults and children, characterized by bronchial hyper-responsiveness, airway inflammation, airflow obstruction, wheezing and breathlessness
The present meta-analysis evaluated the relationship between ADAM metallopeptidase domain 33 (ADAM33) polymorphisms and asthma risk in children
ADAM33, the rs2280091 polymorphism was associated with the increased risk of childhood asthma
Summary
Asthma is a common respiratory disorder in both adults and children, characterized by bronchial hyper-responsiveness, airway inflammation, airflow obstruction, wheezing and breathlessness. The prevalence of asthma in children is increasing worldwide and has become one of the major causes of child hospitalization and morbidity [1]. This disease can be induced by environmental factors (such as bacterial infections and tobacco smoke) and multiple genetic factors [2,3,4]. It has been reported that environmental factors as well as genetic predisposition play important roles in asthma development in children [5,6]. Several candidate genes have been reported to be functionally implicated during the occurrence and development of asthma, such as pro-inflammatory genes, anti-inflammatory genes, airway remodeling genes, immune modulation genes, etc. Several candidate genes have been reported to be functionally implicated during the occurrence and development of asthma, such as pro-inflammatory genes, anti-inflammatory genes, airway remodeling genes, immune modulation genes, etc. [7]
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