Abstract
BackgroundMethanol poisoning (MP) often causes acute mortality and morbidities; however, the association between MP and subsequent mortality has not been well studied.MethodsWe conducted a nationwide population-based cohort study by identifying 621 participants with MP from the Nationwide Poisoning Database and 6210 participants without MP from the Longitudinal Health Insurance Database 2000 by matching the index date at a 1:10 ratio between 1999 and 2012. Comparison of the mortality rate between the two cohorts was performed by following up until 2013.ResultsA total of 249 (40%) participants with MP and 154 (2.5%) participants without MP died during the follow-up (p < 0.001). Statistic analysis showed that participants with MP had a higher risk for mortality than did the participants without MP (adjusted hazard ratio [AHR]: 13.48; 95% confidence interval [CI]: 10.76–16.88). The risk of mortality was highest in the first 6 months after MP (AHR: 480.34; 95% CI: 117.55–1962.75). Hypertension, chronic obstructive pulmonary disease, liver disease, malignancy, drug abuse, and lower monthly income also predicted mortality.ConclusionsMP was associated with increased subsequent mortality. Close follow-up for comorbidity control and socioeconomic assistance are suggested for patients with MP.
Highlights
Methanol poisoning (MP) often causes acute mortality and morbidities; the association between MP and subsequent mortality has not been well studied
Cox proportional hazard regression analysis showed that participants with MP had higher risk for death than did the participants without MP by adjusting for hypertension, diabetes, hyperlipidemia, stroke, coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD), renal disease, liver disease, malignancy, drug abuse, mental disorder, and monthly income, especially in the age subgroups of 20–34 years (AHR: 31.75; 95% Confidence interval (CI): 14.19–71.03) and 35–49 years (AHR: 26.68; 95% CI: 17.25–41.27)
This study showed that MP was associated with increased subsequent mortality
Summary
Methanol poisoning (MP) often causes acute mortality and morbidities; the association between MP and subsequent mortality has not been well studied. Methanol poisoning (MP) is often caused by volunteer or accidental ingestion. The toxicity is not caused by the methanol itself, but by its metabolite, formic acid [1]. Formic acid will accumulate, resulting in metabolic acidosis and inhibition of cytochrome oxidase in the mitochondria, which lead to histotoxic hypoxia [2]. The brain and the visual pathway are the most sensitive organs to the effect of formic acid, whereas other organs may be seriously damaged according to the severity of metabolic acidosis [3]. Studies of methanol mass poisoning in Estonia, Norway, and Czech
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