Association between ACE Gene I/D Polymorphism of Men of Han Nationality in Northern China and the Effects of HiHiLo on Muscle Oxygenation

Abstract

To explore the association between Insertion/Deletion polymorphism of the angiotensin converting enzyme (ACE) gene and the effects of Living High-Exercise High-Training Low (HiHiLo) on muscle oxygenation (MO), Seventy-one healthy men of Han nationality in northern China underwent HiHiLo training for 4 weeks. Training programme was as follows: exposure in hypoxic environment (14.5%~14.8%O2, 10h/day), three times hypoxic training per week (15.4%O2), and training at sea level. Resting MO, exercising MO and resuming MO were measured by non-invasive near infrared spectroscopy (NIRS) before and after the protocol, and the ACE gene I/D polymorphism was detected by PCR. The findings indicated that exercising MO and resuming MO all increased markedly after training (P< 0.05), but resting MO declined. As to genotypes, no significant differences were in the baseline MO among groups before HiHiLo. Increase in resting MO and exercising MO in II and ID groups were more than those in DD groups, but decline in resuming MO in II and ID groups was less than those in DD groups.The present study suggested that HiHiLo could be helpful for developing individual resting MO and exercising MO, but harmful for resuming MO. Moreover, MO of men carrying II and ID probably were more sensitive to the hypoxic training than those carrying DD.