Association between ABCA1 R230C polymorphism, dietary intake, anthropometric measurements and biochemical parameters in subjects with and without metabolic syndrome

Abstract

Approximately, 20% of the adult Mexican population shows a polymorphism (SNP) in the ABCA1 gene (R230C) associated with low HDL‐cholesterol (HDL‐C) concentration, obesity and diabetes. On the other hand, 40–50% of the adults have metabolic syndrome (MetS). Thus, the aim of this study was to evaluate the association between the presence of the ABCA1 polymorphism and food intake on blood lipids, anthropometric measurements, physical activity and energy expenditure in 298 Mexican subjects with and without MetS (71 men, 227 women). The frequency of the non‐common allele (T) was 11%. The frequency of homozygous for the non‐common allele (C230C) and heterozygous (R230C) was 19.3%. The frequency of R230C and C230C of ABCA1 gene was similar in patients with and without MetS. However, the subjects with and without MetS with R230C and C230C SNP, as the energy intake increased the serum HDL‐C increased. However, HDL‐C remained constant as the energy intake increased in women with MetS and R230C and C230C SNP. Grant CONACYT 181685 (to MGC).Grant Funding Source: CONACYT