Abstract
Background: Although ABCA1 gene polymorphisms may be associated with the plasma lipid concentration, the literature has not shown a consistent pattern. In this study, we attempted to elucidate the association between the ABCA1 69C>T, 825V>I, and 230R>C polymorphisms and the plasma lipid concentration through a systematic review and meta-analysis. Methods: We selected studies published up to October 2020 in the PubMed, Web of Science, and Embase databases according to inclusion and exclusion criteria. The mean difference (MD) and 95% confidence interval (CI) were used to assess the relationship between the presence of ABCA1 69C>T, 825V>I, and 230R>C and plasma lipid levels. Meta-analysis was performed using Review Manager (version 5.3). Both Begg’s test and Egger’s regression test of the funnel plot were performed using R Studio software (version 3.6.0) to identify publication bias. Results: We analyzed the data on the ABCA1 69C>T polymorphism involving 14,843 subjects in 11 studies, 825V>I polymorphism involving 2580 subjects in 5 studies, and 230R>C polymorphism involving 4834 subjects in 4 studies. The T allele carriers in 69C>T, II carriers in 825V>I, and C carriers in 230R>C had lower high-density lipoprotein cholesterol levels; the MD (95% CI) was −0.05 mmol/L (95% CI: −0.09 to −0.01, p = 0.02), −0.05 mmol/L (95% CI: −0.09 to −0.00, p = 0.03), and −0.1 mmol/mL (95% CI: −0.12 to −0.07 mmol/L, p < 0.00001), respectively. In the case of 230R>C, the serum total cholesterol concentration of C carriers was significantly lower than that of RR carriers (−0.2 mmol/L, 95% CI: −0.3 to −0.11, p < 0.0001). Conclusion: This meta-analysis demonstrates that the ABCA1 69C>T, 825V>I, and 230R>C polymorphisms could affect the plasma lipid concentration. As the plasma lipid concentration may be related to various diseases, ABCA1 genotyping could be useful for the management of lipid levels.
Highlights
Coronary heart disease (CHD) is a common disease with high morbidity and mortality [1]
Dyslipidemia refers to a condition in which total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels are increased or high-density lipoprotein cholesterol (HDL-C) levels are decreased due to abnormal lipoprotein metabolism
Studies were included if they evaluated the relationship of ATP-binding cassette transporter A1 (ABCA1) 69C>T, 825V>I, and 230R>C with the lipid levels of adults
Summary
Coronary heart disease (CHD) is a common disease with high morbidity and mortality [1]. One of its main functions is to promote the efflux of cellular cholesterol and phospholipids [3] They combine with extracellular apolipoproteins, forming incipient HDL-C. This is the first step of the reverse cholesterol transport process which transports and removes cholesterol and phospholipids from peripheral cells back to the liver, through which ABCA1 is involved in cholesterol homeostasis [4,5,6]. A previous observational study showed that a 50% increase in ABCA1-mediated cholesterol efflux caused a 30% increase in the concentration of HDL-C, resulting in a decreased incidence of coronary artery disease (CAD) by 50% [8]. We attempted to elucidate the association between the ABCA1 69C>T, 825V>I, and 230R>C polymorphisms and the plasma lipid concentration through a systematic review and meta-analysis. As the plasma lipid concentration may be related to various diseases, ABCA1 genotyping could be useful for the management of lipid levels
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