Abstract
Objective — The aim of the study was to evaluate the association between b-fibrinogen gene - 455G/A polymorphism and the plasma fibrinogen level in Chinese patients with different subtypes of coronary heart disease (CHD).Methods and results — We investigated b-fibrinogen gene -455G/A polymorphism and plasma fibrinogen level in non-CHD control subjects (n=466) and CHD patients (n=1,019) including patients with stable angina pectoris (SAP) (n=674), and acute coronary syndrome (ACS) (n=345). Increased plasma fibrinogen levels were observed in the CHD groups compared with the control subjects (ACS: 380.92±92.35mg/dl, SAP: 352.49±94.89mg/dl, control: 311.72±87.09* mg/dl,* P<0.001 vs. ACS and SAP). Individuals with the -455A/A genotype were associated with the highest plasma fibrinogen in the control subjects (P<0.001) and patients with SAP (P<0.001) but not in patients with ACS (P>0.05). Allele frequency and genotype distribution were similar among the three groups (P=0.314).Conclusions — This study demonstrated that elevated plasma fibrinogen level is related to increased CHD risk.The presence of -455A allele is significantly associated with higher fibrinogen in non-CHD control subjects and SAP patients but not in ACS patients while -455G/A polymorphism is not a risk factor for CHD in the Chinese population.
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