Abstract
BackgroundEpidemiological studies have evaluated the association between 3801T>C polymorphism of CYP1A1 gene and the risk for idiopathic male infertility, but the results are inconclusive. We aimed to derive a more precise estimation of the relationship by conducting a meta-analysis of case-control studies.MethodsThis study conformed to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase and CNKI databases were searched through November 2013 to identify relevant studies. Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. Q-test was performed to evaluate between-study heterogeneity and publication bias was appraised using funnel plots. Sensitivity analyses were conducted to evaluate the robustness of meta-analysis findings.ResultsSix studies involving 1,060 cases and 1,225 controls were included in this meta-analysis. Overall, significant associations between 3801T>C polymorphism and idiopathic male infertility risk were observed in allelic comparison (OR = 1.36, 95% CI: 1.01–1.83), homozygous model (OR = 2.18, 95% CI: 1.15–4.12), and recessive model (OR = 1.86, 95% CI: 1.09–3.20), with robust findings according to sensitivity analyses. However, subgroup analyses did not further identify the susceptibility to idiopathic male infertility in all comparisons. Funnel plot inspections did not reveal evidence of publication bias.ConclusionsThe current meta-analysis provides evidence of a significant association between CYP1A1 3801T>C polymorphism and idiopathic male infertility risk. Considering the limitation inherited from the eligible studies, further confirmation in large-scale and well-designed studies is needed.
Highlights
Idiopathic male infertility (IMI) is a global health dilemma affecting approximately 10–15% of the male adults and up to one in six couples, which accounts for 40–50% male infertility problems [1,2,3]
Much attention in the genetic studies has been paid to the cytochrome P450 1A1 (CYP1A1) that plays a curial role in phase I metabolism of polycyclic aromatic hydrocarbons to their ultimate biologically active intermediates that have potential reproductive toxicity in men [5,8]
We used the combination of the search terms: (‘‘CYP1A1’’ or ‘‘cytochrome P450 1A1’’ or ‘‘rs4646903’’), (‘‘idiopathic male infertility’’ or ‘‘male infertility’’ or ‘‘oligozoospermia’’ or ‘‘azoospermia’’ or ‘‘teratospermia’’) and (‘‘polymorphism’’ or ‘‘allele’’ or ‘‘variant’’ or ‘‘mutation’’ or ‘‘gene’’ or ‘‘genotype’’)
Summary
Idiopathic male infertility (IMI) is a global health dilemma affecting approximately 10–15% of the male adults and up to one in six couples, which accounts for 40–50% male infertility problems [1,2,3]. Epidemiological data indicated that damage of xenobiotic to the genetic material might contribute to spermatogenetic failure for about 30% of infertility in males [5]. A number of genetic studies have been done to investigate the contribution of genes encoding to IMI, and some of these studies have revealed the direct relationship between the genotypes and the disease susceptibility [6,7]. The CYP1A1 gene has been shown to be polymorphic, and several polymorphisms have been identified [9]. Several studies have investigated the relationship between the CYP1A1. Epidemiological studies have evaluated the association between 3801T.C polymorphism of CYP1A1 gene and the risk for idiopathic male infertility, but the results are inconclusive. We aimed to derive a more precise estimation of the relationship by conducting a meta-analysis of case-control studies
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