Abstract
Objective:To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women.Methods:Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 (OH)D and calcium levels were measured and mammographic density (MD) was assessed using automated volumetric breast density software, Volpara Research (algorithm version 1.5.1, Volpara solutions Ltd, Wellington, NZ) on the same day. The volumetric breast density (VBD) was categorized as; VG1: 0% - 4.5 %; VG2: 4.6% - 7.5%; VG3: 7.6% – 15.5% and VG4 >15.5%. Mean serum 25(OH)D and calcium levels were compared across the four volumetric breast density categories. The percent volumetric density was also correlated with anthropometric measurements and other related variables.Results:No significant difference was found in mean serum 25 (OH)D level across the four groups (15.87 Vs. 12.40 Vs. 8.99 Vs. 9.68; p-value = 0.106). The percent VBD were found significantly negatively correlated with age (r = - 0.365; p-value = 0.001), weight (r = - 0.575; p-value = 0.001), height (r = - 0.197; p-value = 0.049), and BMI (r = - 0.519; p-value = 0.001). The serum Vitamin D, and calcium levels were not found significantly correlated with percent VBD (p-value > 0.05).Conclusion:No significant association exists between serum 25(OH)D level and breast density.
Highlights
Breast cancer is one of the most prevalent cancers worldwide,[1] with more than 1.2 million people being diagnosed with the disease yearly.[2]
mammographic density (MD) was assessed using automated volumetric breast density software, VolparaResearch.The physics acquisition parameters required by the software were extracted using the FCR console and manually entered into the DICOM header of the raw (“For Processing”) images
No significant difference was found in mean serum vitamin D and calcium levels across the four volumetric breast density categories
Summary
Breast cancer is one of the most prevalent cancers worldwide,[1] with more than 1.2 million people being diagnosed with the disease yearly.[2]. The cultural norms of Pakistani women where early marriages, multiparty and longer breast feeding are common, Pakistani women are still at high risk of developing breast cancer.
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