Association and interaction between dietary patterns and gene polymorphisms in Liangshan residents with hyperuricemia

Tingting Li,Longjian Liu,Shuangjing Li,Wangdong Xu,Zhichao Nie,Hong Jia,Tian Tian

doi:10.1038/s41598-021-04568-y

Tingting Li, Longjian Liu + Show 5 more

Open Access

https://doi.org/10.1038/s41598-021-04568-y

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Abstract

Hyperuricemia (HUA) is associated with dietary and genetic factors. However, studies on dietary patterns and their interaction effect with genes on the risk of HUA are limited. We aimed to explore the association between dietary patterns and HUA, and dietary patterns—gene interactions on the risk of HUA. A population-based cross-sectional study was conducted in adults aged 18 and older in Liangshan Yi Autonomous Prefecture of China. Dietary consumption was collected using a standard Food Frequency Questionnaire. Vein blood samples were collected after overnight fasting, and DNA was extracted from peripheral blood leukocytes. Dietary patterns were derived using principal component and factor analysis. Of the 2646 participants, the prevalence of HUA was 26.8%. Three dietary patterns were classified. Of them, a dietary pattern with higher meat consumption (defined as meat-based) had the strongest association with HUA than a dietary pattern with plant-based or local special diet-based. A higher frequency of T allele at ABCG2 rs2231142 and SLC2A9 rs11722228 loci was observed in participants with HUA than those without HUA. An additive interaction of meat-based dietary pattern with rs2231142 locus was significantly associated with an increased risk of HUA. The relative excess risks of interaction, attributable proportion of interaction, and synergy index (S) were 0.482 (95% CI: 0.012–0.976), 0.203 (95% CI: 0.033–0.374), and 1.544 (95% CI: 1.012–2.355), respectively. In conclusion, a dietary pattern with meat-based was significantly associated with an increased risk of HUA. There was an additive interaction between a meat-based dietary pattern and the ABCG2 rs2231142 locus. Individuals with rs2231142 T allele were at higher risk of HUA than those with rs2231142 GG allele.

Highlights

Hyperuricemia (HUA) is associated with dietary and genetic factors
Three dietary patterns were identified among the Yi people who lived in the Liangshan District of Sichuan Province, China
The main finding of this study is that the meat-based food pattern, which is characterized by a high intake of animal organ meats, seafood, fresh meat, and eggs, was positively associated with an elevated risk of HUA, whereas no significant association was observed between the other two dietary patterns and HUA risk

Summary

Introduction

Studies on dietary patterns and their interaction effect with genes on the risk of HUA are limited. We aimed to explore the association between dietary patterns and HUA, and dietary patterns—gene interactions on the risk of HUA. An additive interaction of meatbased dietary pattern with rs2231142 locus was significantly associated with an increased risk of HUA. A dietary pattern with meat-based was significantly associated with an increased risk of HUA. There was an additive interaction between a meat-based dietary pattern and the ABCG2 rs2231142 locus. A cross-sectional study found that the ‘animal and fried foods’ pattern was associated with a higher prevalence of H UA13, while another study demonstrated that there was no significant association between dietary patterns and HUA in the Chinese p opulation[11]. The association between dietary patterns and HUA remains unclear

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