Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis.

Abstract

Recently, many institutions have investigated the associations of interleukin-17 (IL17) polymorphisms with tuberculosis (TB) susceptibility, while those results are inconsistent. The purpose of this meta-analysis is to comprehensively assess whether IL17A rs22275913, IL17F rs763780, and IL17A rs3748067 polymorphisms are correlated with TB risk. Electronic bibliographic databases were searched for case-control studies which potentially focused on the relationship between the aforementioned polymorphisms and TB risk on October 15th, 2015. Pooled odds ratios (OR) combined with 95% confidence intervals (CI) were employed to assess the associations. There was no significant association of IL-17A rs22275913 polymorphism with susceptibility to TB in Asians or Caucasians. For IL-17A rs3748067 polymorphism, significant associations were observed in Asian (T vs. C: OR 1.461, 95% CI 1.158-1.844, P=0.001; TT vs. CC: OR 1.871, 95% CI 1.140-3.069, P=0.013; TT/TC vs. CC: OR 1.392 95% CI 1.062-1.825, P=0.017; TT vs. OR 1.820, 95% CI 1.111-2.981, P=0.017). For IL-17F rs763780, we detected the significant associations under allele contrast, heterozygote, dominant and recessive models (C vs. T: OR 1.571, 95% CI 1.352-1.824, P=0.000; CT vs. TT: OR 1.624, 95% CI 1.346-1.958, P=0.000; CT/TT vs. TT: OR 1.639, 95% CI 1.381-1.946, P=0.000, respectively). The corresponding results were also detected in Asian populations (C vs. T: OR 1.068, 95% CI 1.380-1.875, P=0.000; CT vs. TT: OR 1.689, 95% CI 1.390-2.053, P=0.000; CT/TT vs. TT: OR 1.695, 95% CI 1.420-2.023, P=0.000), while there were no significant associations in Caucasian. IL-17F rs763780 allele C and IL-17A rs3748067 allele C may be involved in the susceptibility to TB in Asian populations. There were no significant associations between IL-17A rs22275913 polymorphism and risk of TB.