Abstract
The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.
Highlights
Gestational diabetes mellitus (GDM) is one of the common complications in pregnancy.Its prevalence in Asia is 11.5% [1]
In light of the complications caused by gestational diabetes mellitus (GDM) itself and the devastating consequences of depression and related psychological symptoms of anxiety and stress among women with GDM, we suggest performing a study of fourteen candidate genes to elucidate its genotypic effect on symptoms of depression, anxiety and/or stress among GDM women
We found that almost 50% of women with GDM suffered from anxiety symptoms, which was notably higher than symptoms of either depression (13.4%) or stress (11.7%)
Summary
Gestational diabetes mellitus (GDM) is one of the common complications in pregnancy.Its prevalence in Asia is 11.5% [1]. Previous studies reported that the prevalence of depression among women sufferers from GDM stood at 56.7%, while anxiety was 57.7%, and stress was even higher at 62.8% [10,11,12]. GDM and perinatal mental problems undeniably affect all members of the family [13]. This mental condition may reoccur or worsen to postpartum depression [14]. Multiple determinants such as socio-demographical background, maternal and clinical profiles have a reported positive association with psychological symptoms [15,16,17,18,19]
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