Abstract
Objective To explore the association between N-acylsphingosine amidohydrolase(ASAHl)gene and symptom quantitative trait of schizophrenia in Chinese Han Population.Methods Three polymorphic markers(rs3753118,rs3753116 and rs7830490)in ASAH1 gene were genotyped with polymerase chain reaction and restriction fragment length polymorphism in 254 schizophrenic patients.The Positive and Negative Syndrome Scale (PANSS) was used to quantify the phenotypes of schizophrenia.Results (1)There were significant difierence in the positive subseale score among patients with different genotypes of rs3753118(F=3.506,P 0.05).(3)The PANSS total score and the negative score in patients with rs3753118C-rs3753116G haplotype,and in ones with rs3753118C-rs3753116G-rs7830490A haplotype were higller than that in ones with reference haplotype(P<0.05).Conclusion The ASAH1 gene might be associated with symptom quantitative trait in schizophrenia. Key words: Schizophrenia; Quantitative trait; Gene,N-acylsphingosine amidohydrolase
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