Abstract
BackgroundThis study aims to explore the relationships between pre-pregnancy body mass index (BMI), gestational weight gain (GWG), rate of GWG during the second and third trimesters (GWGrate) and birth weight among Chinese women.MethodsWomen were enrolled by 24 hospitals in 15 different provinces in mainland China from July 25th, 2017 to 26 November 2018. Pre-pregnancy BMI, GWG and GWGrate were calculated and divided in to different groups. The multinomial logistic regression model and restrictive cubic spline model were used to explore the relationships.ResultsOf the 3585 participants, women who were underweight, had insufficient GWG or GWGrate had 1.853-, 1850- or 1.524-fold higher risks for delivering small-for-gestational-age (SGA) infant compared with women who had normal BMI, sufficient GWG or GWGrate. Women who were overweight/obese, had excessive GWG or GWGrate had 1.996-, 1676- or 1.673-fold higher risks for delivering large-for-gestational-age (LGA) infant. The effects of GWG and GWGrate on birth weight varied by pre-pregnancy BMI statuses. Dose-response analysis demonstrated L-shaped and S-shaped relationships between pre-pregnancy BMI, GWG, GWGrate and neonatal birth weight.ConclusionsPre-pregnancy BMI, GWG or GWGrate were associated with neonatal birth weight among Chinese women. Both body weight before and during pregnancy should be maintained within the recommendations to prevent abnormal birth weight.
Highlights
This study aims to explore the relationships between pre-pregnancy body mass index (BMI), gestational weight gain (GWG), rate of GWG during the second and third trimesters (GWGrate) and birth weight among Chinese women
In this study, we found that pre-pregnancy underweight and insufficient GWG were associated with higher SGA risk and lower LGA risk while pre-pregnancy overweight or obese and excessive GWG were associated with higher LGA risk and lower SGA risk
The relationships this study found between prepregnancy BMI, GWG and GWGrate are consistent with the findings of some existing studies [21,22,23], including a cohort study located in three provinces in southwest China [24]
Summary
This study aims to explore the relationships between pre-pregnancy body mass index (BMI), gestational weight gain (GWG), rate of GWG during the second and third trimesters (GWGrate) and birth weight among Chinese women. Since the 1980s, the overweight and obesity rates have doubled during the past four decades in more than 70 countries worldwide, and the rates are still increasing [1]. For women of childbearing age, pre-pregnancy body mass index (BMI) is regarded as an important predictor of pregnancy outcomes since abnormal BMI has been verified to be related to a series of adverse maternal and neonatal complications [3,4,5]. Gestational weight gain (GWG) is another factor that impacts fetal development, and insufficient or excessive GWG mostly results in restricted or over development. Asian women have been shown to have the highest prevalence of insufficient GWG (USA 21%, Europe 18% and Asia 31%), while more than half of American women have excessive GWG (USA 51%, Europe 51% and Asia 31%) [6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
