Abstract
Every year approximately 100,000 children with Thalassemia major are born world over, of which 10,000 are born in India. The combination of regular blood transfusions and chelation therapy has dramatically increased the life expectancy of thalassemics into 4th & 5th decades of life. On the other hand, frequent blood transfusion has also led to iron overload with many complications including endocrinopathies, behavioral and neurotic problems, growth failure etc. In the present study analysis of beta thalassemia major cases was done to determine the frequency and extent of complications associated with thalassemia. Two hundred thirty one patients of beta thalassemia were studied in the present investigation. It is concluded that commonest complication of beta thalassemia major is growth failure. Other complications are also not uncommon and involve liver, heart and endocrine glands. This study would help in early detection of the associated complications in beta thalassemia patients which would be quite helpful to reduce the burden of disease through preventive measures.
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