Abstract
The main purpose of this study was to investigate the class I HLA antigens and class II HLA allele frequencies in 164 patients with leukemia: 35 patients with ALL (acute lymphoid leukemia), 50 with AML (acute myeloid leukemia) and 78 with CML (chronic myeloid leukemia). The genotyping of class I HLA was performed by microlymphocytotoxicity and of class II by PCR-SSP (polymerase chain reaction - sequence specific of primers) (One Lambda, Canoga Park, CA, USA). In patients with LLA, frequencies of HLA-B45 and HLA-B56 were higher (P = 0.02; OR = 3.13; 95%IC = 0.94-10.44; P = 0.03; OR = 3.61; 95%IC = 0.47-27.64, respectively), than in controls. In patients with AML, the frequency of HLA-B7 (P = 0.01; OR = 2.41; 95%IC = 1.25-4.67) was higher than in controls. The presence of HLA-B45 (P= 0.01; OR = 3.29; 95%IC = 1.46-7.40), HLA-DRB1*04 (P = 0.002; OR = 2.17; 95%IC = 1.36-3.46) and HLA-DRB1*08 (P = 0.004; OR = 2.36; 95%IC = 1.34-4.16) was associated to increased risk of CML developing. Our results suggest that variants of HLA confer susceptibility to the same forms of leukemia, and could provide new tools for the investigation of genetics and etiology of this disease.
Highlights
The genotyping of class I HLA was performed by microlymphocytotoxicity and of class II by PCR-SSP (One Lambda, Canoga Park, CA, USA)
Tian H, Zhou SY, Liu Zh, Fu YG, Lu FJ, Lin JH, et al Association of HLA – DPB1 alleles with chronic myelogenous leukemia in Southern Chinese hans
Summary
LÚCIA APARECIDA BARION, LUIZA TAMIE TSUNETO, GIULIANA VITORIANO TESTA, SOFIA ROCHA LIEBER, LIGIA DUTRA MARQUES, AFONSO CELSO VIGORITO, FRANCISCO JOSÉ PENTEADO ARANHA, KATIA APARECIDA BRITO CRISTINA MARTINS MIRANDA, CÁRMINO ANTONIO DE SOUZA, JEANE ELIETE LAGUILA VISENTAINER*. O objetivo deste estudo foi investigar a freqüência de antígenos HLA Classe I e de alelos HLA Classe II em 164 pacientes com vários tipos de leucemias: 35 pacientes com LLA (leucemia linfóide aguda), 50 com LMA (leucemia mielóide aguda) e 78 com LMC (leucemia mielóide crônica). Vários estudos de associação entre os sistemas HLA e as leucemias têm sido realizados, muitos dos quais com resultados diferentes e havendo necessidade de confirmá-los através da análise de um número maior de pacientes com leucemia, conforme sugerido por vários autores. O objetivo principal deste estudo foi verificar a existência de associação entre os antígenos HLA-A e -B e os alelos HLA-DRB1 e alguns tipos de leucemias, tais como a LLA, LMA e LMC
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