Abstract
This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine. Patients with a diagnosis of malaria caused by Plasmodium vivax or the V+F mixture (Plasmodium vivax + Plasmodium falciparum) were selected. Group 1 consisted of 74 individuals with a clinical diagnosis of methemoglobinemia and Group 2 consisted of 161 individuals without a clinical diagnosis of methemoglobinemia. The glucose-6-phosphate dehydrogenase deficiency rates (numbers of enzymopenic individuals) in Groups 1 and 2 were 51.3% (38) and 8.7% (14) respectively. These data demonstrated a statistically significant association with methemoglobinemia only among the individuals in Group 1 (p<0.05). Investigation of the relationship between methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency showed that there was a possible association such that enzymopenic individuals may develop methemoglobinemia more frequently.
Highlights
This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine
O estudo foi conduzido na Fundação de Medicina Tropical do Amazonas (FMTAM), Manaus, Amazonas - Brasil, onde foram selecionados pacientes da demanda espontânea de atendimento da Gerência de Malária, com diagnóstico para malária vivax ou mista V+F e da unidade hospitalar “Dr Nelson Antunes”, após concordarem com o termo de consentimento livre e esclarecido
Os indivíduos com deficiência da G6PD apresentaram um odds ratio de 11,8 para metemoglobinemia, quando comparados com os que não eram deficientes
Summary
This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine. O propósito deste estudo foi verificar a associação entre metemoglobinemia e deficiência da G6PD durante o tratamento da infecção malárica com primaquina.
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