Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization

Abstract

TP53INP1, formerly called either TEAP (thymus-expressed acidic protein) or SIP (stress-induced protein), was identified by microarray technology in mouse. It is a novel gene plausibly involved in the function of thymus (Carrier et al., 1999) and is induced by stress during the acute phase of pancreatitis (Tomasini et al., 2001). The human TP53INP1 counterpart (also called p53DINP1: p53-dependent damage-inducible nuclear protein 1, Okamura et al., 2001) and SIP (Tomasini et al., in press) is a proapoptotic gene induced through TP53 activation. This gene is a stress-induced gene with potential antitumoral properties. We report here the localization of TP53INP1 gene to human chromosome 8q22, in a region that shows conserved synteny with region A1–A2 of the murine chromosome 4 where the mouse gene was mapped (Carrier et al., 2000).