Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2β, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F

Abstract

The receptor-type protein tyrosine phosphatase IA-2β gene (mouse gene symbol Ptprn2) encodes a major autoantigen in insulin-dependent diabetes mellitus. We physically mapped Ptprn2 by fluorescence in situ hybridization to band F of mouse chromosome 12, a region that lacks diabetes susceptibility loci. The mapping confirms the proposed synteny of mouse 12F with band q36 of human chromosome 7.