Assignment of Human Potassium Channel Gene KCNA4 (Kv1.4, PCN2) to Chromosome 11q13.4 → q14.1

Abstract

Both electrically excitable and nonexcitable tissues express voltage-sensitive K[sup +] channels. Since the original isolation of the Drosophila Shaker gene encoding voltage-sensitive K[sub +] channels, five additional related gene families have been described: the Shal, Shab, and Shaw families and the K-eag and Slo genes. A seventh family of slowly activating K[sup +] channels, minK of IsK, is structurally unrelated to the others. Seven human genes related to the Shaker subfamily have been described. We recently described the cloning of a fast-inactivating human voltage-gated K[sup +] channel, PCN2. Here we report the mapping of the gene encoding PNC2, designated KNCA4, to chromosome 11 by analyzing its segregation in a panel of reduced human-mouse somatic cell hybrids. In situ hybridization to prometaphase chromoxomes localized KCNA4 to the long arm of chromosome 11 in the region of bands q13.4 [r arrow] q14.1.