Abstract
Interspecific somatic cell hybrids formed by fusion of mouse Cl1D cells with Chinese hamster primary spleen or fibroblast cells were used to form a clone panel with members retaining different combinations of Chinese hamster chromosomes and isozyme markers. Concordant segregation analysis of isozymes and chromosomes among clone panel members enabled the provisional assignment of ADA, ITPA, and AK1 to Chinese hamster chromosome 6. Diphtheria toxin selection for Chinese hamster chromosome 2 segregants in Dede cell X Cl1D somatic cell hybrids indicated AK2 is located on chromosome 2. These assignments extend observations of autosomal linkage group conservation in mammals--a concept further supported by similarity of G-band patterns in certain chromosomal regions bearing homologous loci in Chinese hamsters, humans, and mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
