Assignment of 12 loci to rat chromosome 5: Evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p Arm)

Abstract

Twelve loci have been assigned to rat chromosome 5: aldolase B ( ALDOB), atrial natriuretic factor ( ANF = pronatriodilatin, PND), D4RP1, DSI1, galactosyltransferase ( GGTB2), glucose transporter ( GLUT1), interferon α1 and related interferon α ( INFA), interferon β ( INFB), lymphocyte-specific protein-tyrosine kinase ( LCK), oncogene MOS, α 2U-globulin (major urinary protein, MUP), and orosomucoid ( ORM, also called α 1-acid glycoprotein, AGP). Among these, the interferon α and β genes map in the q22–23 region, which also contains a transformation suppressor gene ( SAI1). The other loci reside outside this region. This study also indicated that the rat genome contains 2 LCK genes, unlike the human and murine genomes. These new assignments on rat chromosome 5 demonstrate that this chromosome is highly homologous to mouse chromosome 4 and carries synteny groups conserved on human chromosome 9 (interferon α and β, galactosyltransferase, orosomucoid, and aldolase B genes) and on the short arm of human chromosome 1 ( MYCL, glucose transporter, protein kinase LCK, and atrial natriuretic factor genes).