Abstract
BackgroundIn Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. Zinc and copper are essential Trace element needed to strengthen the immune system and also useful in the fight against tuberculosis. The Cu / Zn ratio is a good indicator of oxidative stress.The principal aim of this study was to evaluate the serum concentration of some trace element and determine the Cu / Zn ratio in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) before and after second line treatment of TB.MethodsBlood samples were obtained from 100 MDR-TB patients after confirmation of their status through the microscopic and molecular diagnosis of resistance to Isoniazid and Rifampicin by GeneXpert. The concentration level of zinc and copper were determined using flame air / acetylene atomic absorption spectrometer (AAS) Type Varian Spectr AA-20 Victoria, Australlia.ResultsA significant decrease in zinc levels (P < 0.05) and an increased Cu / Zn ratio (P < 0.05) was observed in MDR-TB patients compared to controls TB free. During treatment a significant reduction in Cu / Zn ratio (P < 0.05) was observed compared to the initial result.ConclusionsThe decrease in serum zinc level and the high Cu / Zn ratio could explain the immune system dysfunction and the high level of oxidative stress in patients with MDR-TB. Therefore the evaluation of the zinc and copper status could represent essential parameters in monitoring of TB second line treatment for better treatment management.
Highlights
In Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006
In 2014, the World Health Organization (WHO) estimated 480,000 the number of people who contracted MDR-TB and about 190,000 deaths attributed to this form of TB [1]
The aim of our study is to evaluate serum copper and zinc level and determine the Cu / Zn ratio in MDR-TB patients before treatment, after 3 months treatment and after 6 months second line TB treatment, respectively
Summary
In Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. The principal aim of this study was to evaluate the serum concentration of some trace element and determine the Cu / Zn ratio in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) before and after second line treatment of TB. In Côte d’Ivoire, the national tuberculosis control program (NTBC) reported that the recent socio-political crisis in Côte d’Ivoire has encouraged the emergence of the multidrug resistance pulmonary TB form of which prevalence is estimated to 2.5% in 2006 [2]. The outbreak of this disease and its spread are due to malnutrition and deterioration of the immune system [3, 4]. Other studies have reported that some TB drugs could affect the nutritional profile of the TB patient receiving treatment [5, 6]
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