Abstract
BackgroundMany species of mushroom contain an assortment of free radical scavengers (Phenolics and Flavonoids compounds) that have made them nutritionally beneficial and a source of expansion of drug production. In this study, we examined the preventive and remedial role of total phenol extract from Pleurotus columbines (TP) in alleviating the consequences of cyclophosphamide (CTX) on the ovaries of female rats. Rats were randomly assigned to four groups: healthy controls, cyclophosphamide (CTX), received a TP (100 mg/kg) orally daily for 14 days and curative group: CTX-TP, we determined and identified a total phenol from a mushroom extract and examined it as an antioxidant agent. To investigate the therapeutic influence, it was administrated 2 weeks after CTX. To assess the impact of TP on ovarian damage caused by CTX, ovarian hormone tests were performed such as luteinizing hormone (LH), 17-β-estradiol (E2), and anti-mullerian hormone (AMH). Besides, follicle-stimulating hormone (FSH) in serum was evaluated, and histopathological analysis of the ovary was examined. ResultsThis study indicates that treatment with TP decreased the severity of cyclophosphamide-induced ovary injury by reducing inflammation and apoptotic effects and increasing the activity of antioxidants. ConclusionsTP could be used to alleviate cyclophosphamide-induced ovary injury.
Highlights
Many species of mushroom contain an assortment of free radical scavengers (Phenolics and Flavonoids compounds) that have made them nutritionally beneficial and a source of expansion of drug production
The results illustrated that the mushroom P. columbinus was rich in carbohydrates and protein (43.0% and 17.0%, respectively) but low in fiber and fat (2.5% and 4.5% Dry weight (DW), respectively) with an ash content of 5.7% DW
Total phenolics and flavonoids compounds The amount of 28.13 mg/g gallic acid equivalent/mL of extract was found
Summary
Many species of mushroom contain an assortment of free radical scavengers (Phenolics and Flavonoids compounds) that have made them nutritionally beneficial and a source of expansion of drug production. We examined the preventive and remedial role of total phenol extract from Pleurotus columbines (TP) in alleviating the consequences of cyclophosphamide (CTX) on the ovaries of female rats. Rats were randomly assigned to four groups: healthy controls, cyclophosphamide (CTX), received a TP (100 mg/kg) orally daily for 14 days and curative group: CTX-TP, we determined and identified a total phenol from a mushroom extract and examined it as an antioxidant agent. Follicle-stimulating hormone (FSH) in serum was evaluated, and histopathological analysis of the ovary was examined. An inhibitory effect of cyclophosphamide has been detected on the hypothalamic-pituitary axis in rhesus monkeys [6] This finding shows ovarian failure itself as excessive gonadal insufficiency, leading to menopause and usually irreversible sterility. The present study was intended to appraise the antioxidant activity of an aqueous extract of P. columbinus and its impact on premature ovarian failure (POF) triggered by chemotherapy in rats
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