Abstract
AbstractBackgroundThe reduction in serum levels of erythrocytes and vitamin B12 may be related to the cognitive decline in elderly people with Alzheimer's.MethodA case control study was carried out in healthy patients (n = 39) and diagnosed with Alzheimer's Disease (n = 44). Inclusion and exclusion criteria were established. We performed a complete blood count and B12 and folic acid evaluation. The collections, material processing and sample analysis took place according to the recommendations of the Brazilian Society of Clinical Pathology.Resultin patients with Alzheimer's disease, vitamin B12 levels were 267.72 pgml, while in healthy subjects, 388.52 pg / ml. Red blood cells in patients with Alzheimer's, 4.39; and in the healthy 4.75.Conclusionthe early diagnosis of Alzheimer's disease represents a primary goal, and the role of biomarkers appears to be crucial to the routine of the clinical environment. Our studies have demonstrated low levels of B12, being compatible with literature that associates low concentrations of B12 with cognitive decline.
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