Abstract
Introduction: Measles vaccine virus (MeV) has shown to possess profound oncolytic capability. However, tumor resistances to MeV might endanger broad clinical success, a hypothesis which is underlined by our analysis of the NCI-60 tumor cell panel being infected with a suicide gene-armed vector (MeV ld-SCD); this SCD suicide gene locally converts the non-toxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU), which is able to kill also neighbouring cells by diffusion („bystander effect”).
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