Assessment of variations in selective biochemical parameters and its correlation with age and gender in COVID-19 patients of Ujjain district: A retrospective study

Abstract

Background: At Ujjain district, in which the current study is based, has no prior studies examining the variations of liver function tests in the resident population. Aims and Objectives: The present study was undertaken to assess the variation in selective biochemical parameters and their correlation with age and gender in COVID-19 patients of Ujjain district: A retrospective study. Materials and Methods: 199 cases of confirmed COVID-19 patients from June 2020 to November 2020 were admitted to R. D. Gardi Medical College, Ujjain, Madhya Pradesh, were part of the study. Aspartate aminotransferases (AST), Alanine aminotransferases (ALT), Alkaline phosphatases (ALP), Total protein (TP), Total bilirubin (TB), C-reactive protein (CRP), Lactate dehydrogenase (LDH), sodium, and potassium parameters were recorded in the study participants. AST, ALT, TP, TB, CRP, and LDH were analyzed using vitros 5600 integrated system which is a dry chemistry autoanalyzer of ortho clinical diagnostics. Sodium and potassium analysis were analyzed on the vitros 5600 integrated system by using the direct potentiometry principle. The data were obtained from the patient information sheet from the MRD of our hospital. Results: The study results present the age-wise and gender-wise correlation of the parameters. There was an increase in the AST, ALT, CRP, and LDH levels in both male and female participants. However, the difference is not statistically significant. ALP, TP, TB, and potassium levels are within the normal limits in male and female participants. Albumin levels were decreased in male and female participants. However, the difference was not statistically significant. Sodium levels were significantly decreased (P<0.05) in males when compared with females. Conclusion: The study assessed the variations in selective biochemical parameters and their correlation with inflammatory markers in COVID-19 patients of the Ujjain district. The study results help to understand the biochemical aspects of the Covid disease. Further, detailed studies are recommended to understand the role of the biochemical parameter which helps for early diagnosis to save the life of the covid patients in general.