Abstract
Canine visceral leishmaniasis is an increasingly important public health problem. Dogs infected by Leishmania infantum are the main domestic reservoir of the parasite and play a key role in its transmission to humans. Recent findings have helped in the development of novel diagnostic methods, and of control measures such as vaccines, some of which are already commercially available. However, quantitative procedures should be followed to confirm whether these vaccines elicit a cell-mediated immune response. The present work describes the need for this evaluation, and the techniques available for confirming this type of immune response.
Highlights
WHO Collaborating Centre for Leishmaniasis, Laboratory for Reference and Research in Parasitology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
canine visceral leishmaniasis (CVL) is a growing public health concern whose control requires the use of effective measures to prevent infection and the development of the disease
Vaccines for CVL represent an important advance for this control, but the complexity of the protective response that these vaccines have to induce in the host makes it difficult their obtaining and the assessment of their efficacy
Summary
WHO Collaborating Centre for Leishmaniasis, Laboratory for Reference and Research in Parasitology, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain. The dichotomy in the reaction to Leishmania is seen in naturally infected dogs from the same disease-endemic area developing either severe CVL or remaining asymptomatic. Partial protection against CVL has been reported after immunization with sonicated or autoclaved promastigotes [41, 42], with purified and recombinant Leishmania proteins
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