Assessment of troponin I level in patients with acute myocardial infarction and its impact on clinical outcome

Abstract

Introduction: Coronary Artery disease is one of the major causes of Mortatlity I the world that included Myocardial ischemia and infarction. Cardiac toponins are (troponin- I and Troponin -T) the markers of myocardial ischemia and they are the sign of Myocardial damage. They can provide important diagnostic and prognostic information. Aim : In the present study the correlation of clinical presentation, complication and outcome with reference of different level (mild, moderate and severe) of elevated troponin enzyme level was studied. Material and method: 100 patientspresented with acute myocardial infarct ion were studied for clinical presentation (hemodynamics, heart failure, mechanical complication, angina, shock) and ICCU stay and total hospital stay, recurrent angina, heart failure, re-infarct, morbidity and mortality was recorded. Their cardiac troponin- I level was measured and corelated accordingly in group 1 (mild elevation: cTnIlevel baseline (0.004) totentimes), group 2 (moderate elevation: cTnIlevel ten times to hundredtimes) and group 3 (severe elevation: cTnIlevel morethan hundredtimes). RESULTS: Significantly greater number of patients with recurrent angina were having severely elevated Troponin-I level. Relocation of patient in ICCU was more with patient with severely elevated level. Severity of cardiac failure and Troponin-I levels were found to be significantly associated with each other.