Abstract
The detection of traumatic axonal injury (TAI) has greatly benefitted from beta-APP immunostaining. The reliable identification of TAI though remains a challenge, particularly so in a brain subject to the effects of significantly raised intracranial pressure with mass effect, associated vascular axonal injury often confounding reliable interpretation. The overdiagnosis of traumatic axonal injury and the overinterpretation thereof may also be promoted by the failure to recognise other conditions which could cause axonal injury.
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