Abstract
A specific and direct method for the determination of 11 trace elements (Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Ti and Zn) in penicillin G was worked out in an exploratory way using inductively coupled plasma-atomic emission spectrometry (ICP-AES) with a V-groove nebulizer for highly concentrated solutions. This particular sample introduction system was chosen to improve the expected insufficient detection limits of ICP-AES (low [μg · g −1 range). Perfectly matrix-matched, buffer stabilized, calibration standard solutions were prepared on the basis of high pure PeG (15% w v ). Trace elements were added as EDTA-chelates under buffered conditions and after sonication to prevent irreversible precipitation of penicillanic acid. The limits of detection for the trace elements investigated were found to be in the ng · g −1 range. Relative standard deviations were found to be lower than 3%, and recoveries within ± 5% deviation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
