Assessment of Toxicity and Therapeutic Effects of Goose Bone in a Rat Model

Md Sakib Hossen,Md Ashraful Hasan,Alamgir Kabir,Md Yousuf Ali,Shahad Saif Khandker,Md Salman Shakil,Md Aminul Islam,Tareq Hossan,Md Ibrahim Khalil,Siew Hua Gan

doi:10.1155/2019/1943601

Abstract

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided into four groups (n = 8) and were orally administrated with three doses (30, 60, and 120 mg/kg) of goose bone once daily for 21 days as compared to control animals (received only drinking water). Goose bone did not cause any significant changes on body weight, relative organ weight, and percentage water content at any of the administered doses. There were also no significant alterations in hematological parameters seen. All three doses administered significantly reduced the triglyceride levels as well as the atherogenic index of plasma (AIP). Animals treated with 120 mg/kg doses had significantly reduced alkaline phosphatase (ALP) activity as compared to the control group. There was no significant alteration on other serum biochemical parameters seen. Additionally, histopathological findings confirmed that there was no inflammatory, necrotic, or other toxicological feature seen for all three doses. It is concluded that goose bone is nontoxic and is safe for consumption besides having the potential to be investigated for the treatment of high triglycerides or liver-related disorder.

Highlights

From ancient times, various traditional drugs have been utilized in the treatment of several chronic diseases for curing and for prevention of diseases
Goose bone is processed into powder and is inserted into capsules which are used for treatment
Goose bone treatment is very popular in folk medicine, there are no scientific data to support its use or to evaluate its toxic effects. erefore, the aim of this study is to assess the possible toxic effect of goose bone in a rat model by investigating the biochemical, hematological, and histopathological parameters

Summary

Introduction

Various traditional drugs have been utilized in the treatment of several chronic diseases for curing and for prevention of diseases. Goose bone is a traditional remedy utilized in Malay traditional medicine for several years. It has been widely applied for both external and internal complications, especially in the treatment of fractured bones. E folklore claims on its use may be substantiated by the fact that calcium is an important mineral for the bones, joints, nerve, and muscle [1,2,3]. Goose bone treatment is very popular in folk medicine, there are no scientific data to support its use or to evaluate its toxic effects. Erefore, the aim of this study is to assess the possible toxic effect of goose bone in a rat model by investigating the biochemical, hematological, and histopathological parameters Goose bone treatment is very popular in folk medicine, there are no scientific data to support its use or to evaluate its toxic effects. erefore, the aim of this study is to assess the possible toxic effect of goose bone in a rat model by investigating the biochemical, hematological, and histopathological parameters

Objectives

Methods

Findings

Discussion

Conclusion