Abstract
This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2–L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2–L4, and BMDDFN, were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H (p < 0.001). The General Linear Model (GLM) regression results were as follows: BMDTotal = 1.473–0.002 R/H + 0.007 Xc/H, r = 0.684; BMDL2–L4 = 1.526–0.002 R/H + 0.012 Xc/H, r = 0.655; BMDDFN = 1.304–0.002 R/H + Xc/H, r = 0.680; p < 0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMDTotal, BMDL2–L4 and BMDDFN. R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.
Highlights
This study aimed to investigate the relationship between bone mineral density (BMD) and heightadjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA)
There was no significant difference in the age and Body mass index (BMI) between men and women
This study showed that bioelectrical impedance vector analysis (BIVA) outcomes including PhA, height-adjusted R (R/H), and Xc (Xc/H), were related to BMD levels in the whole body, spine, and proximal femur in the elderly population
Summary
This study aimed to investigate the relationship between bone mineral density (BMD) and heightadjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2–L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2–L4, and BMDDFN, were calculated using a Hologic DXA scanner. Changes in bone mineral content (BMC) and BMD are age- and gender-dependent. BMD should be measured at specific fracture sites of interest such as the spine, proximal femur, and forearm for accurate risk assessment. A DXA scanner uses two different energies of X-ray to partition the body mass into BMC and soft tissue and calculate the corresponding BMD. BIA is a well-known method for calculating body composition in clinical practice and field studies owing to its portability, low cost, and high precision. The performance for predicting BMC using mineral estimates by BIA was reported to be high in correlation but with the limited agreement in healthy young a dults[7]
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