Assessment of the value of summed stress score and phase analysis of gated myocardial perfusion imaging in the severity of coronary artery lesion

Bo Cui ,Baoping Liu ,Xinli Xie

doi:10.3760/cma.j.issn.1673-4114.2018.02.004

Abstract

Objective To assesse the value of summed stress score (SSS) and phase analysis of gated myocardial perfusion imaging (GMPI) in the severity of coronary artery lesion. Methods Eighty-nine patients with chest pain who underwent coronary angiography and 99Tcm-methoxyisobutylisonitrile (99Tcm-MIBI) two-day stress-rest GMPI were enrolled in this study. Among them, 52 patients were diagnosed with coronary heart disease by coronary angiography; 26 patients had coronary atherosclerosis and 11 patients were normal. The degree of coronary artery lesion was represented by Gensini score. SSS and phase histogram bandwidth (BW), standard deviation (SD), and entropy were derived using a 17-segment visual semi-quantitative method and the quantitative gated SPECT software phase analysis to analyze the correlation of the parameters with the Gensini score. The differences of the above parameters among coronary heart disease group, coronary artery sclerosis group, and normal group were compared. Kruskal-Wallis test, ANOVA, correlation analysis, ridge regression, and paired t test were used for statistical methods. Results (1)Univariate analysis showed that Gensini score gradually increased with the increase of GMPI parameters. (2)Ridge regression analysis showed that BW was the most significant parameter that reflected the severity of coronary artery lesion, followed by SSS, entropy, and SD(t=6.692, 3.688, 3.559 and 2.896, all P 0.05). The differences in BW, SD and entropy between rest and stress GMPI in 89 patients were not significantly different (t=0.283, 1.121 and 0.726, all P>0.05). Conclusions SSS, BW, SD, and entropy have certain value in assessing the degree of coronary artery disease. Rest and stress GMPI have similar values in assessing left ventricular synchrony. Key words: Gated myocardial perfusion imaging; Coronary heart disease; Chase analysis; Summed stress score; Gensini score

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