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Abstract
Introduction. Since the end of the last century, dysfunction of the trace element composition of blood in various forms of scoliosis has been an urgent problem in several studies. Hidden deficiency of trace elements, associated with insufficient food consumption or low absorption in the body, can cause progressive bone deformities. In this context, special importance is attached to trace elements, such as copper, selenium, zinc, boron, manganese, and others. The study of the trace element concentrations in patients with congenital spinal deformities currently is an important and significant task.
 Aim. We assess the trace element composition of whole blood in children with congenital deformities of the thoracic and lumbar vertebral columns.
 Materials and methods. We analyzed the trace element status of blood in 108 patients (aged 216 years) with congenital deformities of the thoracic and lumbar spine (CSD). The congenital vertebral anomalies included disorders of formation, fusion, and/or segmentation of the vertebrae. The control group consisted of 35 healthy children of identical age. Blood ethylenediaminetetraacetic acid (EDTA) was examined using mass spectrometry with inductively coupled plasma (ICP-MS ThermoScientific, iCAP RQ).
 Results and discussion. The content of 33 essential and conditionally essential trace elements in the whole blood of patients with CSD was determined. In 37% of patients the zinc, copper, selenium, and chromium levels were decreased compared with the controls. In 7% and 89% of patients the selenium and of chromium levels, respectively, were especially low, below the sensitivity of the device.
 Conclusion. The statistically significantly low content of zinc, copper, selenium, and chromium in the whole blood of patients with CSD may have a role in the pathogenesis of the disorders. Further investigations are needed to evaluate their importance as a marker of disease progression.
Highlights
Since the end of the last century, dysfunction of the trace element composition of blood in various forms of scoliosis has been an urgent problem in several studies
Special importance is attached to trace elements, such as copper, selenium, zinc, boron, manganese, and others
In 37% of patients the zinc, copper, selenium, and chromium levels were decreased compared with the controls
Summary
Оценка микроэлементного состава крови у детей с врожденными деформациями грудного и поясничного отделов позвоночника (предварительное сообщение). Исследование концентрации микроэлементного состава у пациентов с врожденными деформациями позвоночника (ВДП) в настоящее время является важной и значимой задачей. Цель данного исследования заключалась в оценке микроэлементного состава цельной крови у детей с ВДП грудной и поясничной локализации. Проведен анализ микроэлементного статуса крови 108 пациентов в возрасте от двух до 16 лет с врожденными деформациями грудного и поясничного отделов позвоночника на фоне врожденных аномалий развития позвонков: нарушения формирования, слияния и/или сегментации. У 37 % пациентов выявлено снижение содержания ряда микроэлементов крови — цинка, меди, селена и хрома по сравнению с контролем. Достоверное снижение в крови больных с ВДП содержания хрома, цинка и селена может вносить свой вклад в патогенез этих пороков развития и требует дальнейшего изучения для оценки их значения как маркера прогрессирования деформации. For citation: Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2019;7(1):
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