Abstract
The maximum incidence of pertussis in young children confirms the importance of their timely immunization.The goal is – to study the timeliness of vaccination against whooping cough, causes of violation of the vaccination schedule in young children, the effect of recombinant interferon-a on the post-vaccination period.Materials and methods: the vaccination history and data on the course of the post-vaccination period after immunization with DPT and DaPT vaccines of 469 children at the age of 3–24 months were studied.Results. The analysis showed that 14,9% of the observed children were not vaccinated against whooping cough in a timely manner. Of these: 34,3% had a written refusal to vaccinate (5.1% of the total number of observed children), in 32,8% of cases, the vaccination schedule was violated due to late arrival of parents, 32,9% of children by the start of immunization had medical challenges, and only half of them had justified contraindications. Non-serious side effects associated with immunization were observed in 11.3% of cases, statistically more often with DTP (22,0%) compared with DaPT (5.,5%). General and local reactions, in general, were recorded on DPT (6,9% and 15,1%, respectively) and less often developed with the use of DaPT (1,0% and 4,5%, respectively). Within 1 month after immunization, 16,2% of the observed children had an acute respiratory viral infection of varying severity. Those who did not receive antiviral therapy more often carried the disease in a moderate and severe form, which in all cases led to the postponement of the administration of the second and third doses of the vaccine.Conclusion. To increase the timeliness of vaccination of children against whooping cough, medical professionals should persistently remind parents about the timing of turnout for the next vaccination, when making medical withdrawals, be guided by modern methodological documents and instructions for vaccines. The use of antiviral and immunomodulatory effects of IFN-alpha drugs allows us to comply with the recommended schedule for vaccination of children with a high risk of SARS in the post-vaccination period.
Highlights
The maximum incidence of pertussis in young children confirms the importance of their timely immunization
The analysis showed that 14,9% of the observed children were not vaccinated against whooping cough in a timely manner
Comparison of adverse events following immunisation with acellular and whole-cell pertussis vaccines: A systematic review
Summary
Резюме Максимальная заболеваемость коклюшем детей раннего возраста подтверждает важность их своевременной иммунизации. Цель: изучить своевременность вакцинации против коклюша, причины нарушения графика прививок у детей раннего возраста, влияние препаратов рекомбинантного интерферона-aльфа на течение поствакцинального периода. Материалы и методы: изучен прививочный анамнез и данные о течении поствакцинального периода после иммунизации вакцинами АКДС и препаратами с бесклеточным коклюшным компонентом 469 детей в возрасте от 3 мес. Что 14,9% наблюдаемых детей оказались своевременно не привиты против коклюша, из них: у 34,3% оформлен письменный отказ от прививки (5,1% от общего числа наблюдаемых детей), в 32,8% случаев график вакцинации был нарушен из-за несвоевременной явки родителей, 32,9% детей к началу иммунизации имели медицинские отводы, причем только у половины противопоказания были обоснованные. В основном, регистрировались на АКДС (6,9% и 15,1% соответственно) и реже развивались при использовании препаратов с бесклеточным коклюшным компонентом (1,0% и 4,5% соответственно). Для увеличения своевременности вакцинации детей против коклюша медицинские работники должны настойчиво напоминать родителям о сроках
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