Abstract
Poly-herbals combination was applied to enhance biological activity, particularly antioxidant activity. This present study was purposed to assess the synergistic interaction of a combination of five traditional Indonesian herbal plants through a simultaneous and integrated statistical technique. The plants were extracted using maceration, and purification was conducted before extraction to eliminate the ballast compounds. A simplex lattice design comprising 35 design points was utilized to understand herbal combinations' main effect and interaction through multiple linear regression analysis on the antioxidant activity using DPPH and ABTS assays. The results showed that C. longa, P. niruri, and C. xanthorrhiza had the most potent antioxidant activity than M. oleifera and C. asiatica. The presence of C. longa modulated the synergistic interaction between combinations. Meanwhile, the non-curcuminoid content in C. xanthorrhiza played a fundamental role in reducing the antioxidant activity. The synergistic interaction could enhance the antioxidant activity through poly-herbals combination. In addition, particular consideration should be withdrawn by antagonism interaction in the poly-herbals combination for reducing the biological activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
