Assessment of the study of longitudinal systolic function by 2D strain in hypertensive patients with preserved LVEF

Abstract

Hypertension is a risk factor for cardiovascular disease. It causes LV hypertrophy (LVH). LVH as well as patterns of abnormal geometry have been associated with adverse outcomes. Global longitudinal strain (GLS) has been used to detect early subclinical myocardial dysfunction in a broad spectrum of cardiac conditions and provides a novel approach for LV risk assessment in patients with hypertension. Assess the clinical and echocardiographic factors associated with and predictive for early impairment of left ventricular function as assessed using GLS evaluation in hypertensive patients. Cross-sectional descriptive study, with a number of 130 hypertensive and with the objective of evaluating the study of longitudinal function by 2D strain in patients with systemic hypertension with preserved LVEF and the determination of predictors factors of the decrease GLS in this population. A complete study echo cardiographic, including LVEF biplane Simpson method, calculation of left ventricular mass indexed and relative parietal thickness, analysis diastolic function and the study of longitudinal strain of the LV. The prevalence of (LVH) was 66%. 49% presented a concentric hypertrophy, 73% had a relative wall thickness (RWT) > 0.42.18% had severe diastolic dysfunction with elevation in filling pressure. The mean GLS was found to be −16.9 ± 3.2%, low GLS values (> −17%) were found in 45.5% of the general population. In particular, 34.4% of the patients had no LVH and 50.7% of them presented LVH. Statistical analysis revealed significant correlation between the decrease in GLS and diabetes, the values of blood pressure and elevated filling pressures. The evaluation of longitudinal systolic function by 2D strain provides new insight of myocardial function in hypertension that could improve the pathophysiological understanding and identify high-risk heart failure patients eligible for preventive strategies.