Abstract
Background: Tramadol is opioid analgesic which acts on the central nervous system. Most of clinicians may not routinely consider naloxone for tramadol cases because of risks of inducing seizures. This study aims to evaluate the effect of naloxone in the prognosis of patients with tramadol intoxication and its role in inducing seizures. Methods: This study included both prospective and retrospective studies. The prospective study involved 30 patients with tramadol intoxication admitted to the poison control center during the year of 2015 who received naloxone while the retrospective study involved 30 patients with tramadol intoxication admitted to the poison control center during the years of 2011-2012 who didn't receive naloxone. Results: The studied patients were in the age 16-60 years range with male predominance (75%). Most of patients (65%) were tramadol addict. The mean delay time was 3.32 ± 1.50 hours while the dose of ingested tramadol among studied patients was 1439.29 ± 804.49 mg. The most common symptom on admission among studied patients was sweating (66.7%), cyanosis (61.7%) and bradypnea (60%). The seizure was significantly lower in naloxone group (6.6%) when compared with the non naloxone group (50%). Death occurred in 23.3% of the non naloxone group and only 3.3% of naloxone group. Conclusion: The incidence of seizure was lower in patients with tramadol toxicity who given naloxone which means that naloxone not precipitate seizure in patients with tramadol toxicity as what was thought by the majority of previous studies.
Highlights
Tramadol is an opioid analgesic acts directly on the central nervous system
Most of clinicians may not routinely consider naloxone for tramadol cases because of risks of inducing seizures or are unclear of its efficacy so this study aims to evaluate the effect of naloxone in in the prognosis of patients with tramadol intoxication and its role in inducing seizures
The prospective study involved 30 patients with tramadol intoxication admitted to the poison control center during the year of 2015 who received naloxone while the retrospective study involved 30 patients with tramadol intoxication admitted to the poison control center during the years of 2011-2012 who didn't not receive naloxone
Summary
Tramadol is an opioid analgesic acts directly on the central nervous system. Naloxone is a pure opioid antagonist competitively blocks the effects of opioids without any agonist effects It is indicated if tramadol overdose is accompanied with CNS depression or respiratory depression with no effect on its serotonin or norepinephrine action [10,11]. Most of clinicians may not routinely consider naloxone for tramadol cases because of risks of inducing seizures or are unclear of its efficacy so this study aims to evaluate the effect of naloxone in in the prognosis of patients with tramadol intoxication and its role in inducing seizures. This study aims to evaluate the effect of naloxone in the prognosis of patients with tramadol intoxication and its role in inducing seizures
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
