Assessment of the Role of Ginsenoside RB1 Active Substance in Alginate/Chitosan/Lovastatin Composite Films

Thi-Loc Thach,Tuan-Anh Nguyen,Minh-Thanh Do,An-Quan Vo,Long-Giang Bach,Quang-Tung Nguyen,Thuy-Chinh Nguyen,Hoang Thai

doi:10.1155/2020/5807974

Abstract

This article reports the effect of ginsenoside Rb1 on some properties, morphology, and the drug release process of the chitosan (CS)/alginate (AG)/lovastatin (LOV) composite films prepared by a solution method using different contents of ginsenoside Rb1. The ratio of AG/CS was fixed at 4/1 (wt.%/wt.%), the content of LOV was 10 wt.%, and the content of ginsenoside Rb1 was changed from 1 to 5 wt.%. The results of scanning electron microscopy and Fourier transform infrared spectroscopy analysis showed that the composite films have a heterogeneous structure and the ginsenoside Rb1 content influenced on the structure of composite films. The presence of ginsenoside Rb1 did not influence on the melting temperature of these films but caused a significant difference in the melting enthalpy of the films. The ginsenoside Rb1 was also contributed positively on the LOV release from these films in different pH buffer solutions. The LOV release process from these films included two stages (fast/burst release and slow/control release). It was increased remarkably by the synergic effect of LOV and ginsenoside Rb1 in the drug release process. From the obtained results, we suggested that ginsenoside Rb1 plays an important role not only in the enhancement of health and immunity as general but also as an efficient agent in control of the LOV size as well as LOV drug release from the composite films.

Highlights

Panax notoginsengs as well as ginsengs are herbaceous plants whose root is used as a medicine to make the most rare and nutritious Oriental medicine
The results showed that LOV and ginsenoside Rb1 had a synergistic effect which influenced positively on the morphology, properties, and drug release ability of these films [23]
With the addition of ginsenoside Rb1 into the AG/CS/LOV composite films, it was recognized to have a strong shift in NH3OC and the hydroxyl group in the Fourier transform infrared spectroscopy (FTIR) spectra of CS, AG, LOV, Time

Summary

Introduction

Panax notoginsengs as well as ginsengs are herbaceous plants whose root is used as a medicine to make the most rare and nutritious Oriental medicine. We prepared and investigated the characteristics, morphology of the AG/CS/LOV composite films, and ability to control in vitro drug release from these composite films [8, 19,20,21,22]. The results indicated that the AG/CS ratio of 4/1 and the LOV content of 10 wt.% (compare with the mass total of AG and CS) were most suitable for preparation of the AG/CS/LOV composite film This film had higher drug loading ability, thermal stability, and better control drug release in comparison with the films which use a different AG/CS ratio and LOV content [19]. The results showed that LOV and ginsenoside Rb1 had a synergistic effect which influenced positively on the morphology, properties, and drug release ability of these films [23]. We expect that the combination of ginsenoside Rb1 and LOV in AG/CS blend will reduce the cholesterol concentration for treatment of cardiovascular diseases for patients and increase in the immunity, strengthening the health of ginsenoside Rb1 thanks to the synergistic effect of ginsenoside Rb1 and LOV

Experimental

Results and Discussion

Conclusion