Abstract

SUMMARyThe risk of transfusion‐transmitted viral infections is presently exceedingly low, and mathematical modeling is necessary to estimate the magnitude of the residual risk. Direct calculation of the risk from prospective studies of transfusion recipients is either not possible or prohibitively expensive. The accumulated experience with the incidence/window‐period model indicates that this approach can predict (1) the approximate residual risk of transfusion‐transmitted infections that are characterized by an infectious window period before appearance of infectious disease markers in peripheral blood; and (2) the approximate risk reduction that can be expected with implementation of new tests.

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