Abstract
Objective: To evaluate the association of MMP-9 promoter gene polymorphism in generalized chronic periodontitis patients of an Indian population . Material and Methods: Eighty patients were selected and divided into case and control groups (n=40). Patients included were aged 15-60 years of both genders and diagnosed with chronic periodontitis. Peripheral venous blood samples were obtained, and genomic DNA was isolated by a 'salting out' method. Three possible genotypes were distinguished by three distinct banding patterns, depending on the presence or absence of the Sph I restriction site: CC as allele 1, TT as allele 2, and CT, respectively. Statistical analysis was carried out by applying the Chi-squared test and One-way ANOVA. Results: There was a significant difference in MMP-9 genotypes between Chronic periodontitis patients and healthy controls. Odds ratios for CT genotype and combination of CT and TT genotypes were 3.125 (95% confidence interval, p=0.028) and 3.667 (95% confidence interval, p=0.006) relative to subjects with CC genotype, respectively . Conclusion: The present study revealed an association of MMP-9 (-1562 C/T) gene polymorphism with generalised chronic periodontitis.
Highlights
Periodontal diseases contribute significantly to the global burden of oral diseases
The present study revealed an association of MMP-9 (-1562 C/T) gene polymorphism with generalised chronic periodontitis
This study revealed an association of MMP-9 (-1562 C/T) gene polymorphism with generalised chronic periodontitis
Summary
Periodontal diseases contribute significantly to the global burden of oral diseases. They are initiated by microbial plaque, which accumulates in the gingival crevice region and induces an inflammatory response. The primary inflammation, i.e., gingivitis, may progress in specific susceptible individuals to the chronic destructive inflammatory condition termed periodontitis. The bone and other tooth-supporting tissues are destroyed, and the changes are irreversible [1,2,3]. The periodontal disease process appears to be modified by genetic factors, environmental factors, and acquired conditions [4]. While microbial and other environmental factors are believed to initiate disease, there is strong supporting evidence that genes play a role in the predisposition and progression of periodontal diseases [5,6,7]
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