Abstract
Objective: There is an increasing evidence supporting the role of a regulated cytokine network in the ovulatory process. In humans, it has been shown that follicular fluid (FF) exerts chemotactic activity toward granulocytes and that activity is related to the outcome of in vitro fertilization (IVF) treatment. IL-6 is a regulator of inflammation and immunity, which may be a physiologic link between the endocrine and the immune systems. It also modulates secretion of other cytokines, promotes T-cell activation and B-cell differentiation. The objective of this study was to investigate the role of IL-6 in the periovulatory FF during IVF cycles.
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